ANTIMICROBIAL RESISTANCE SOLUTIONS
WITH DR. JOHN H. REX
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R&D Insight
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Antimicrobial resistance poses a catastrophic threat. If we don’t act now, any one of us could go into hospital in 20 years for minor surgery and die because of an ordinary infection that can’t be treated by antibiotics. And routine operations like hip replacements or organ transplants could be deadly because of the risk of infection.
Dame Sally Davies Tweet
Public meeting on the LPAD Pathway: Post-meeting thoughts (wonkish)
The hunt for oral antibiotics: Beyond Lipinski’s Rule of Five
FDA Workshop: Animal Models To Support Antibacterial Development (5 Mar 2020, post-meeting notes)
Melinta goes bankrupt / Never let a good crisis go to waste
NIAID workshop: What is a robust PK-PD package?
Scary, Scarier, Scariest (Part 2): What can YOU do about it?
Chemical vs. drugs (Part 2): How do you discriminate? / More on halicin
How hard (and how) to Pull? Net value of Pull via a Transferrable Exclusivity Extension (TEE)
FDA analysis of 40-years of antibacterial development: Dheman et al.
FDA Workshop: Animal models in support of narrow-spectrum agents for A. baumannii and P. aeruginosa
Novel Biology, Novel Utility, & the Illusion of Skill: What to develop? What to reward?
The 6 meanings of “Lack of Access” (UNSLAP)
The thoughtless person playing with penicillin treatment is morally responsible for the death of the man who succumbs to infection with the penicillin-resistant organism.
Alexander Fleming Tweet
The bipartisan PASTEUR Act is the strongest bill ever written to strengthen antibiotic development and use. It will fix our market failures, expand the pipeline for next generation antibiotics, and save lives. We can’t sit on our hands as this public health crisis arrives – we have to act now.
U.S. Senator Michael Bennet Tweet